ROOT CAUSES CLINIC

MCAS Supplement Reference Guide

Find the supplements in your care plan. Learn about each option and how to use it.

Order through Root Causes Clinic

  • Professional brands: Fullscript buys directly from the brands it carries.

  • Keep your care team informed: We can review your orders and the supplement list you choose to share.

  • Simple refills: Choose scheduled auto refills for products in your care plan.

Patient discounts off suggested retail prices.

Extra savings on eligible first orders and scheduled auto refills.

Sign in or create a free Fullscript account to view your pricing and refill options.

Open My Root Causes Clinic Store →

Start low. Add one at a time. Build as you feel stable.

Use only the products your care team has recommended. You do not need every layer or every supplement.

  • These options may help with histamine-related symptoms. Choose only what is in your care plan.

    Handout reference: Quercetin 500–1,000 mg a day; luteolin 50–200 mg a day; vitamin C 500–2,000 mg a day; PEA 300–600 mg once or twice a day. These are reference ranges, not a starting dose for everyone. DAO is taken before a histamine-rich meal as directed for that product.

    Check the label: Combination formulas may contain quercetin, vitamin C, nettle, PEA, curcumin or resveratrol. Avoid doubling up. Nettle root and nettle leaf are different products.

    DAO enzymes

    Vitamin C

    Quercetin and flavonoid combinations

    Nettle

    PEA alternatives

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • Use this layer to address needs found in your history, diet or lab results.

    Handout reference: Magnesium 200–400 mg of elemental magnesium a day; zinc 10–30 mg a day when indicated; riboflavin (B2) 10–50 mg a day. Your care team should guide B6, copper and selenium use. Vitamin D should follow your needs and lab results.

    Check the label: Count elemental magnesium, not the weight of the whole compound. The B2 product below contains 100 mg per capsule, which is above the handout range. Review the dose before use. A separate vitamin D product is not included in this selection.

    Magnesium alternatives

    Targeted nutrient support

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • Gut support depends on your symptoms and how you respond. Probiotics are not one-size-fits-all.

    Handout reference: L-glutamine 2–5 g once or twice a day. Follow product-specific directions for butyrate and enzymes. Digestive enzymes are generally used with meals. Your care team should guide the probiotic strain, starting amount and any gradual increase.

    Check the label: The two enzyme formulas below differ; one includes betaine HCl. Butyrate formulas also differ. Zinc carnosine is discussed in the handout, but no product is linked in this selection.

    Butyrate and tributyrin alternatives

    Glutamine

    Digestive enzyme alternatives

    Probiotic alternatives

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • This layer focuses on antioxidant support. Add products only when your care team recommends them.

    Handout reference: NAC 600–1,200 mg a day; alpha-lipoic acid 100–600 mg a day; glycine 1–3 g a day. Your starting dose may be lower.

    Check the label: NAC strengths vary. Some formulas add selenium. See Layer 1 for vitamin C and Layer 2 for B2 and selenium. A standalone glycine product is not included here. New or worse symptoms are a reason to pause and contact your care team.

    NAC alternatives

    Alpha-lipoic acid

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • B vitamins, choline and TMG should fit your care plan. More is not always better.

    Handout reference: TMG 500–1,500 mg a day; choline 250–500 mg a day. B12, folate, B2 and B6 doses depend on your needs and response.

    Check the label: Folinic acid and methylfolate are different forms. The 5 mg methylfolate product is five times the strength of a 1 mg option. They are not direct dose swaps. One B12 formula also includes folinic acid. TMG powder needs careful measuring. Choline compounds and citicoline do not provide the same amount of choline per milligram.

    TMG alternatives

    Choline alternatives

    B12 and folate alternatives

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • Choose these options based on your goals, symptoms and response.

    Handout reference: EPA plus DHA 1–2 g a day; curcumin 500–1,000 mg once or twice a day, depending on the formula; resveratrol 100–500 mg a day; L-theanine 100–200 mg once or twice a day. Bromelain should be compared by enzyme activity as well as milligrams.

    Check the label: Curcumin formulas differ in absorption and are not direct dose swaps. One omega-3 formula adds vitamin D3. Count the combined EPA and DHA amount. See Layer 1 for PEA options. Rutin is discussed in the handout, but no product is linked here.

    Curcumin

    Resveratrol

    Omega-3 alternatives

    Bromelain

    L-Theanine

    Open a product to check its current label and available sizes in the Root Causes Clinic Fullscript store. Confirm the size before you order.

  • Use your care plan first. The six layers are a way to organize options. They are not a schedule that everyone must complete. Products in the same group are often choices, not a list to take together.

    Start with the amount your care team recommends. Add one product at a time and allow time to see how you feel. Check your medicines, allergies and other supplements with your care team before starting.

    If symptoms get worse, pause the new product and contact your care team. Do not assume a reaction means a supplement is working. Seek urgent medical help for severe symptoms such as trouble breathing or fainting.

    Tell your care team if you are pregnant, nursing, preparing for surgery, or have kidney or liver disease. Supplements can interact with medicines and may not suit every person.

    This guide is for education. It does not replace your personal care plan or medical care.

  • Product links open the Root Causes Clinic Fullscript store. You may be asked to sign in or create an account. Check the current ingredients, label directions, strength, size and price before you order.

    Root Causes Clinic earns revenue from purchases made through our Fullscript store. You may buy supplements elsewhere.

    Availability and labels can change. If a product is unavailable, ask your care team before choosing a replacement. A similar name does not mean the same ingredients or dose.

    Open the Root Causes Clinic Fullscript store